BISPECIFIC ANTIBODY-MEDIATED CANCER THERAPY WITH CYTOKINE-INDUCED KILLER CELL

摘要

Provided are compositions comprising a MSBODY and a cytotoxic immune cell (e. g., Cytokine-induced killer cell) to form Armed Activated CIK cells (ACCs), wherein the MSBODY comprising a first antigen binding moiety that has specificity for a tumor antigen, and a second antigen binding moiety that binds to the cell. Provided are also methods preparing a composition comprising a MSBODY and a cytotoxic immune cell, and methods for treating patients with CIK cells armed with bispecific antibodies.