Polypeptides for treating and/or limiting influenza infection

摘要

Polypeptides are disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection.

主权项

1. A polypeptide comprising an amino acid sequence according to general formula II
R1-R2-R3-R4-R5-R6-R7-R8-R9-Ala-R10-R11-Phe (SEQ ID NO: 83), wherein R1 is selected from the group consisting of Phe and Val; R2 is selected from the group consisting of Ser, Ala, Phe, Gly, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Thr, and Val; R3 is selected from the group consisting of Glu, and Asp; R4 is selected from the group consisting of Asn, His, Ile, Lys, Leu, Met, Arg, Ser, and Thr; R5 is selected from the group consisting of Leu, Phe, Ile, Met, Asn, Gln, and Val; R6 is selected from the group consisting of Ala, Asp, Lys, Met, Asn, Gln, Arg, Glu, and Val; R7 is selected from the group consisting of Phe, Asp, Asn, and Tyr; R8 is selected from the group consisting of Glu, Ala, Asp, Gly, His, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, and Tip; R9 is selected from the group consisting of Leu, Phe, Ile, Met, and Val; R10 is selected from the group consisting of Leu, Ile, Met, and Tyr; and R11 is selected from the group consisting of Ser, Ala, Gly, and Tyr;