METHODS OF DIAGNOSING AND TREATING FIBROSIS

摘要

The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.

主权项

1. A method of diagnosing a fibrotic condition in a subject, said method comprising:
measuring the level of trimethylation at lysine residue 27 of histone-3 (“H3K27”) in a biological sample from the subject; comparing the level of H3K27 trimethylation in the biological sample to a standard level of H3K27 trimethylation; and diagnosing the presence or absence of a fibrotic condition based on said comparing.