发明名称 Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
摘要 Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.
申请公布号 US9242007(B2) 申请公布日期 2016.01.26
申请号 US201414152979 申请日期 2014.01.10
申请人 EnGeneIC Molecular Delivery Pty. Ltd. 发明人 Brahmbhatt Himanshu;MacDiarmid Jennifer
分类号 A61K48/00;C07H21/02;C07H21/04;A61K47/46;A61K47/48;C07K16/12;C07K16/28;C12N15/11;C12N15/113;A61K31/713 主分类号 A61K48/00
代理机构 Foley & Lardner LLP 代理人 Foley & Lardner LLP
主权项 1. A method of delivering a functional nucleic acid and a chemotherapy drug, comprising contacting: (a) a first intact, bacterially derived minicell that contains (i) a functional nucleic acid molecule or (ii) a plasmid comprising a segment that encodes a functional nucleic acid molecule, and (b) a second intact, bacterially derived minicell that contains a chemotherapy drug with a target tumor cell, wherein the functional nucleic acid molecule targets a transcript encoding a protein in the tumor cell that contributes to drug resistance to the chemotherapy drug in the tumor cell.
地址 Sydney AU