发明名称 |
VACCINES AGAINST AN ONCOGENIC ISOFORM OF ESR1 AND METHODS OF USING THE SAME |
摘要 |
Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding an ESR1 polypeptide or a truncation, deletion or substitution mutant thereof. Methods of using the vaccine inc luding the polynucleotide encoding the ESR1 polypeptide to treat a cancer or precancer are also provided. |
申请公布号 |
WO2016007504(A1) |
申请公布日期 |
2016.01.14 |
申请号 |
WO2015US39367 |
申请日期 |
2015.07.07 |
申请人 |
DUKE UNIVERSITY |
发明人 |
LYERLY, JERBERT, K.;OSADA, TAKUYA;HARTMAN, ZACHARY, C. |
分类号 |
A61K39/00;A61P35/00;C07K1/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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