The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGFs effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Paricularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired.
申请公布号
EP2964673(A2)
申请公布日期
2016.01.13
申请号
EP20140767985
申请日期
2014.03.14
申请人
ALDER BIOPHARMACEUTICALS, INC.
发明人
DUTZAR, BENJAMIN, H.;ANDERSON, KATIE;KOVACEVICH, BRIAN, R.;FELDHAUS, ANDREW, L.;LATHAM, JOHN, A.;GARCIA-MARTINEZ, LEON, F.