Vaccine composition

摘要

A multi-valent vaccine composition is described comprising a conjugate of the capsular polysaccharide of H. influenzae b not adsorbed onto an aluminum adjuvant salt, and two or more further bacterial polysaccharides. A multi-valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.

主权项

1. A multivalent immunogenic composition comprising the following components:
(a) killed whole-cell Bordetella pertussis, (b) tetanus toxoid, (c) diphtheria toxoid, (d) Hepatitis B surface antigen, (e) a conjugate of a carrier protein and the capsular polysaccharide of Haemophilus influenzae type B and (f) one or more conjugates of a carrier protein and the capsular polysaccharide of a bacterium selected from the group consisting of Neisseria meningitidis type A and N. meningitidis type C.