MATERIAL AND METHOD FOR TREATING INTERNAL CAVITIES

摘要

A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of Pluronic F-127, PEG-400, HPMC and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.

主权项

1. A method of treating a urinary tract cancer comprising:
obtaining a pharmaceutical composition comprising an effective amount of a therapeutic agent and a thermoreversible hydrogel; wherein the thermoreversible hydrogel comprises: (i) 18% (w/w) to 40% (w/w) ethylene oxide/propylene oxide block copolymer, (ii) 0.05% (w/w) to 0.5% (w/w) HPMC, and (iii) water; and administering the pharmaceutical composition to a human in need thereof.