| 发明名称 |
SUSTAINED-RELEASE SOLID PREPARATION FOR ORAL USE |
| 摘要 |
It is intended to avoid dose dumping of a drug and improve the dissolution properties of the drug in the lower gastrointestinal tract, and thereby provide a sustained-release matrix preparation for oral administration that reliably exhibits its main pharmacological effect when orally administered once or twice a day. The present invention provides a sustained-release matrix preparation comprising (A) a pharmacologically active drug, (B) a combination of cellulose derivatives, and (C) mannitol. |
| 申请公布号 |
US2015366810(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201514841778 |
申请日期 |
2015.09.01 |
| 申请人 |
Daiichi Sankyo Company, Limited |
发明人 |
Kanamaru Taro;Tajiri Shinichiro;Fukui Sachiko;Yoshida Kazuhiro |
| 分类号 |
A61K9/20;A61K31/403;A61K31/522;A61K31/437 |
主分类号 |
A61K9/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A sustained-release matrix preparation comprising:
(A) a pharmacologically active drug, (B) a combination of cellulose derivatives consisting of:
(i) hydroxypropyl methylcellulose acetate succinate,(ii) hydroxypropyl cellulose having a viscosity of 150 to 400 mPa·s and/or 1000 to 4000 mPa·s, and(iii) hydroxypropyl cellulose having a viscosity of 3.0 to 5.9 mPa·s, and (C) mannitol. |
| 地址 |
Tokyo JP |
