| 发明名称 |
COMPOSITION FOR TREATMENT OF PATHOGENS THAT ARE RESISTANT TO TETRACYCLINES |
| 摘要 |
The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram-positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens. |
| 申请公布号 |
US2015359791(A1) |
申请公布日期 |
2015.12.17 |
| 申请号 |
US201414765446 |
申请日期 |
2014.02.03 |
| 申请人 |
BIOVERSYS AG |
发明人 |
Schneider Peter;Riedl Rainer;Tigges Marcel;Gitzinger Marc;Pieren Michel;Levi Assaf;Sephton Mark;Schellhorn Birgit;Zueger Patrik;Brand Michael;Gygax Daniel;Spies Peter |
| 分类号 |
A61K31/495;A61K31/166;C07D295/192;C07C235/60;C07C233/18;A61K31/165;C07C233/25;A61K31/167;C07C233/29;C07C235/66;C07C235/84;C07D285/135;A61K31/433;A61K31/65;C07C233/73 |
主分类号 |
A61K31/495 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical composition comprising
(a) one or more tetracyclines; (b) a TetR binding compound preventing TetR from dissociation of the tetO operator sequence in the presence of the inducing antibiotic tetracycline. |
| 地址 |
Basel CH |
