| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an animal population having an essentially identical metabolome suitable for a reliable metabolome study and analysis. <P>SOLUTION: The invention relates to a method for providing an animal population having an essentially identical metabolome comprising compiling an animal population being of essentially the same age, keeping the animal population for a time period sufficient for acclimatization under the following housing conditions: (i) constant temperature, (ii) constant humidity, (iii) physical separation of the animals of the animal population, (iv) feeding ad libitum, (wherein the food to be fed is essentially free of chemical or microbial contaminants), (v) drinking ad libitum, (wherein the drinking liquid is essentially free of chemical or microbial contaminants), (vi) constant illumination period, and providing the animal population after the time period. Further, the invention relates to methods for the identification of a compound which effects the metabolome of an animal, or methods for the identification of a marker for such compounds. Moreover, the invention encompasses methods for the identification of such compounds or markers thereof comprising metabolically analyzing a sample from at least one animal of an animal population. <P>COPYRIGHT: (C)2012,JPO&INPIT |
