发明名称 |
INJECTABLE DEPOT FORMULATION COMPRISING CRYSTALS OF ILOPERIDONE |
摘要 |
An injectable depot formulation comprising crystals having structure (I) wherein R is (FII) and the X50 value of the crystals is from 1 to 200 microns. Depot formulations containing crystals of iloperidone or its metabolites have the following advantages: (i) release of the crystals in plasma can be correlated with the size of the crystals; (ii) absorption of the crystals in plasma can be correlated with the size of the crystals; (iii) the particle size of the crystals can be controlled by crystal engineering and/or milling; and (iv) the crystals are stable upon storage, and stable to sterilization procedures, such as gamma irradiation.
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申请公布号 |
US2013012542(A1) |
申请公布日期 |
2013.01.10 |
申请号 |
US201213618753 |
申请日期 |
2012.09.14 |
申请人 |
NOVARTIS AG;WIECKHUSEN DIERK;GLAUSCH ALEXANDRA;AHLHEIM MARKUS |
发明人 |
WIECKHUSEN DIERK;GLAUSCH ALEXANDRA;AHLHEIM MARKUS |
分类号 |
C07D413/04;A61K9/10;A61K31/454;A61K47/10;A61K47/14;A61K47/24;A61K47/26;A61K47/34;A61K47/36;A61K47/38;A61P25/18;A61P25/28 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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