RECOMBINANT TRAIL PROTEIN AND PREPARATION METHOD AND USE THEREOF

摘要

Provided is a nucleic acid fragment, the nucleotide sequence thereof being shown in SEQ ID NO: 1. Provided is a recombinant protein encoded by said nucleic acid fragment, and a preparation method and use of said recombinant protein. Also provided are a conjugate of a recombinant protein modified by PEG, and a preparation method and use of said recombinant protein. The recombinant protein has anti-tumor activity, and acts in synergy with a proteasome inhibitor; the PEG modification of the recombinant protein, while retaining anti-tumor drug effects, also has improved stability and a longer half-life.