发明名称 System and method for producing tissue-engineered material
摘要 A system for producing a tissue-engineered material includes a hollow member and a mechanical stimulating unit. The hollow member is adapted to be implanted in a peritoneal cavity, and is to be positioned in the peritoneal cavity in a manner that a part of the hollow member contacts an inner wall surface of the peritoneal cavity for enabling formation of a biological tissue that encapsulates the hollow member. The mechanical stimulation unit is coupled to the hollow member and configured to provide a periodic mechanical stimulus to the biological tissue by periodically causing the hollow member to expand and contract. A method for producing the aforesaid tissue-engineered material is also disclosed.
申请公布号 US9212345(B2) 申请公布日期 2015.12.15
申请号 US201313958899 申请日期 2013.08.05
申请人 National Cheng Kung University 发明人 Guo How-Ran;Chen Chao-Lin;Hu Jin-Jia;Lee Yung-Chun;Chung Chung-Jen
分类号 C12M1/42;A61F2/06 主分类号 C12M1/42
代理机构 Nixon & Vanderhye P.C. 代理人 Nixon & Vanderhye P.C.
主权项 1. A method for producing a tissue-engineered material in a peritoneal cavity of a living subject, said method comprising the following steps of: (a) implanting a hollow member in the peritoneal cavity, wherein the hollow member is made of a biocompatible and fluid-impermeable material that is expansible and contractible and is positioned in the peritoneal cavity in a manner that a part of the hollow member contacts an inner wall surface of the peritoneal cavity for enabling formation of a biological tissue that encapsulates the hollow member; and (b) during a stimulation session, providing a periodic mechanical stimulus to the biological tissue being formed on the hollow member by periodically introducing a fluid to flow into and out of the hollow member to cause the hollow member to expand and contract accordingly; wherein, in step (a), the hollow member has an elastic segment that has opposite ends, that is elastically deformable, and that is disposed in the peritoneal cavity, and a pair of securing subcutaneous segments that extend from and are in fluid communication with the opposite ends of the elastic segment respectively, that extend outwardly of the peritoneal cavity, and that position the elastic segment in the peritoneal cavity.
地址 Tainan TW