| 摘要 |
<p>(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2014/189393 A3 27 November 2014 (27.11.2014) W I P 0 I P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 487/22 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/NZ2014/000096 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 26 May 2014 (26.05.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 611064 24 May 2013 (24.05.2013) NZ 611061 24 May 2013 (24.05.2013) NZ (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, (71) Applicants : HAMPTON, Mark Barry [NZ/NZ]; 17 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Tainui Street, Somerfield, Christchurch (NZ). SEL- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, WOOD, Andrew Ian [NZ/NZ]; 1 Oldham Lane, The EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Wood, Nelson, 7010 (NZ). SHI, Feng [CN/AU]; 9 Wal- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, lace Street, Eastwood, New South Wales 2122 (AU). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (74) Agent: PARKER, Stephen Robert; Level 31, Vero KM, ML, MR, NE, SN, TD, TG). Centre, 48 Shortland Street, Auckland, 1010 (NZ). Published: - with international search report (Art. 21(3)) [Continued on next page] (54) Title: BIOACTIVE COMPOUNDS (57) Abstract: The invention relates to novel bioact ive polycyclic ether compounds comprising a spiro 176(2 234(2H : 09 linked five-membered cyclic imine. In particular, the 3.6 invention relates to a compound designated por timine, its congeners and the use of these compounds 1 4, in anticancer therapy. In a second aspect the inven 4-94 tion provides a pharmaceutical preparation compris 192,1.98 ing as active ingredient a congener of the first aspect 4. of the invention. Preferably, the pharmaceutical pre 3.7 .1 paration is indicated for use in the treatment of sub jects with neoplasia. More preferably, the pharma 280 5.06 ceutical preparation is indicated for use in the treat ment of subjects with lymphoid malignancies. Prefer 1.67 4A5 ably, the lymphoid malignancies are selected from the group consisting of: chronic lymphocytic leukaemia (CLL) and pediatric acute lymphoblastic leukaemia (ALL). W O 20 14/1893 93 A 3 ||llI II||lV|IIlllIllII1|||1||I|I ||V|I |||||I|||I||||||I|D||||I|||||||||||||| - before the expiration of the time limit for amending the (88) Date of publication of the international search report: claims and to be republished in the event of receipt of 15 January 2015 amendments (Rule 48.2(h))</p> |
