| 摘要 |
Methods for diagnosing and for evaluating the prognosis of a cancer patient, particularly a breast cancer patient, are provided. The methods include determining expression levels of at least five biomarkers in a body sample including a cancer cell from the patient, where expression levels of the biomarkers are indicative of cancer prognosis. Overexpression of the biomarkers of the invention is indicative of a poor prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The methods of the invention can be used in combination with assessment of conventional clinical factors and permit a more accurate evaluation of breast cancer prognosis. |
| 主权项 |
1. A method for evaluating the prognosis of a breast cancer patient, comprising determining the expression levels of the RNA transcripts or their expression products of at least five biomarkers selected from the group consisting of RRAGD, FABP5, UCHL1, GAL, PLOD, DDIT4, VEGF, ADM, ANGPTL4, NDRG1, NP, SLC16A3, and C14ORF58 in a sample comprising a cancer cell from said patient, normalized against the expression levels of all RNA transcripts or their expression products in said sample, or of a reference set of RNA transcripts or their expression products in said sample, wherein expression of said biomarkers is indicative of prognosis, thereby evaluating the prognosis of said breast cancer patient. |
