发明名称 |
BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS |
摘要 |
<p>The invention concerns benzamide compounds of formula (I), wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4 cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).</p> |
申请公布号 |
CA2625970(C) |
申请公布日期 |
2015.12.01 |
申请号 |
CA20062625970 |
申请日期 |
2006.10.17 |
申请人 |
ASTRAZENECA AB |
发明人 |
ANDREWS, DAVID MICHAEL;STOKES, ELAINE SOPHIE ELIZABETH;TURNER, ANDREW;WARING, MICHAEL JAMES |
分类号 |
C07D401/06;A61K31/454;A61P35/00 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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