发明名称 |
Method for producing humanized antibody derived from parent rabbit antibody that binds to desired antigen and humanized antibody or antibody fragment produced by said method |
摘要 |
The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies. |
申请公布号 |
IL202232(A) |
申请公布日期 |
2015.11.30 |
申请号 |
IL20090202232 |
申请日期 |
2009.11.19 |
申请人 |
ALDERBIO HOLDINGS LLC;ALDER BIOPHARMACEUTICALS INC.;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
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分类号 |
A61K;C07K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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