| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to pyrazoline dione derivative of formula,as well as to its pharmaceutically acceptable salt, where Ris selected from hydrogen; possibly substituted C-Calkyl; possibly substituted phenyl; possibly substituted C-Calkylphenyl; possibly substituted phenylC-Calkyl; possibly substituted pyridyl; possibly substituted C-Calkylpyridyl; and possibly substituted pyridylC-Calkyl; Ris hydrogen; Ris hydrogen; R, R, Rand Rare hydrogen; R, R, Rand Rare independently selected from hydrogen atoms and C-Calkyls; Ris selected from hydrogen; -CHRR; possibly substituted C-Calkoxy-carbonyl, possibly substituted -C(O)-phenyl; possibly substituted C-Calkylphenyl; possibly substituted phenylC-Calkyl, possibly substituted C-Calkylheteroaryl or possibly substituted heteroarylC-Calkyl, where heteroaryl is selected from pyridyl, pyrrolyl, pyrimidinyl, furyl, imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl and 1,2,3-triazinyl; Rand Rare independently selected from hydrogen; possibly substituted phenyl; possibly substituted heteroaryl, where heteroaryl is selected from pyridyl, pyrrolyl, pyrimidinyl, furyl, imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl and 1,2,3-triazinyl; X is selected from O, NR, S and S(O); n is integer number, selected from 0 and 1; with term "substituted" meaning that said group is substituted with 1-5 substituents, selected from "C-Calkyl", "C-Calkoxy" and "halogens". Invention also relates to pharmaceutical composition, based on formula (I) compound, intermediate compound of formula,method of obtaining formula (I) and (II) compounds.EFFECT: novel pyrazoline dione derivatives, useful for inhibition of activity or function of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH-oxidase), have been obtained.17 cl, 2 tbl, 23 ex |
