发明名称 |
USE OF MICROPEROXIDASES FOR THE TREATMENT OF CARBOXYHEMOGLOBINEMIA |
摘要 |
It is disclosed herein that microperoxidases are capable of binding carbon monoxide (CO) with high affinity and displacing CO from hemoglobin, thereby acting as CO scavengers. The present disclosure provides methods of treating carboxyhemoglobinemia (or CO poisoning) in a subject by administering a therapeutically amount of an isolated or recombinant microperoxidase. Methods of removing CO from hemoglobin in blood or tissue by administering a therapeutically amount of an isolated or recombinant microperoxidase are also described. Methods of determining the effectiveness of a microperoxidase for removing CO from hemoglobin are further described. |
申请公布号 |
WO2015179344(A1) |
申请公布日期 |
2015.11.26 |
申请号 |
WO2015US31483 |
申请日期 |
2015.05.19 |
申请人 |
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
GLADWIN, MARK, THOMAS;TEJERO BRAVO, JESUS |
分类号 |
A61K38/04;A61K31/409;A61P7/00 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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