IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS

摘要

This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.

主权项

1. A compound that comprises a structure as in formula (I): wherein R1═H, OH, SH, NH2, or substituted or unsubstituted alkyl, alkoxy, alkylthio, or alkylamino; R2═H, alkyl, or substituted alkyl; Y═N or C; R3 is absent if Y═N; or is H, alkyl, substituted alkyl, or combined with R4 to form a carbocycle or heterocycle with the carbon atoms of the pyridine ring to which they are connected if Y═C; R4 is H, or substituted or unsubstituted alkyl, alkoxy, alkylthio, or alkylamino when not combined with R3 to form a carbocycle or heterocycle with the carbon atoms of the pyridine ring to which they are connected; or is combined with R3 to form a carbocycle or heterocycle with the carbon atoms of the pyridine ring to which they are connected; and R8 is a biodegradable polymer or unit thereof.