摘要 |
The invention relates to a process for the preparation of Grignard compounds using a continuous method which involves the reaction of an organic halide dissolved in an organic solvent with metallic magnesium which, together with the activator solution in an organic solvent, fills the flow reactor or optionally a system of flow reactors, and subsequently, the resulting reaction mixture is fed into the terminal flow reactor containing metallic magnesium in order to achieve complete conversion of the organic halide, whereby preferably the organic solvent is re-circulated to flow reactors in a form of vapour. |
申请人 |
ZAKLADY FARMACEUTYCZNE POLPHARMA SA;SZEJA, WIESLAW;HELMAN, JAN;KIRAGA, KRZYSZTOF;DERFLA, SEBASTIAN |
发明人 |
SZEJA, WIESLAW;HELMAN, JAN;KIRAGA, KRZYSZTOF;DERFLA, SEBASTIAN |