发明名称 |
HSP70 MODULATORS AND METHODS FOR MAKING AND USING THE SAME |
摘要 |
The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound. |
申请公布号 |
CA2948621(A1) |
申请公布日期 |
2015.11.19 |
申请号 |
CA20152948621 |
申请日期 |
2015.05.13 |
申请人 |
MEMORIAL SLOAN KETTERING CANCER CENTER |
发明人 |
CHIOSIS, GABRIELA;KANG, YANLONG;PATEL, HARDIK J.;PATEL, MAULIK;OCHIANA, STEFAN;RODINA, ANNA;TALDONE, TONY;SHRESTHA, LIZA |
分类号 |
C07D239/56;A61K31/506;A61P35/00;C07D401/12;C07D401/14;C07D405/12;C07D417/12 |
主分类号 |
C07D239/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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