Plasma microRNA for the detection of early colorectal cancer

摘要

The present invention refers to a method for diagnosing or detecting advanced colorectal adenomas and optionally colorectal neoplasia in a human subject comprising the steps of:
- measuring an overall expression pattern or level of microRNAs obtained from one or more biological samples of the subject, wherein at least those miRNAs are miR18a and optionally miR19a and miR19b, or miR18a and optionally miR19a and miR19b and miR15b; and
- comparing the overall expression pattern of microRNAs from the biological sample of the subject suspected of suffering from advanced colorectal adenomas or colorectal neoplasia with the overall expression pattern of the microRNAs from a biological sample of a normal subject, wherein the normal subject is a healthy subject not suffering from advanced colorectal adenomas or colorectal neoplasia, wherein overexpression of miR18a is indicative of advanced colorectal adenomas and wherein overexpression of miR19a and miR19b, or miR19a and miR19b and miR15b is indicative of colorectal neoplasia.