发明名称 |
SHIP1 MODULATORS AND METHODS RELATED THERETO |
摘要 |
Compounds of formula (I): where, n, R1, R4a, R4b, R5, R7 and R8 are defined herein, or pharmaceutically acceptable salts thereof, are described herein. The disclosed compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof. |
申请公布号 |
EP2943470(A1) |
申请公布日期 |
2015.11.18 |
申请号 |
EP20140702673 |
申请日期 |
2014.01.07 |
申请人 |
AQUINOX PHARMACEUTICALS (CANADA) INC. |
发明人 |
MACKENZIE, LLOYD, F.;MACRURY, THOMAS, B.;HARWIG, CURTIS;BOGUCKI, DAVID;RAYMOND, JEFFERY, R.;PETTIGREW, JEREMY, D.;KHLEBNIKOV, VLADIMIR;SHAN, RUDONG |
分类号 |
C07D213/82;A61K31/05;A61K31/09;C07C39/08;C07C43/205;C07C49/83;C07C61/39;C07C233/76;C07D213/38;C07D213/89;C07D233/64;C07D401/12 |
主分类号 |
C07D213/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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