| 发明名称 |
NANOPARTICLES FOR BRAIN TUMOR IMAGING |
| 摘要 |
Nanoparticle having a chitosan-polyethylene oxide oligomer copolymer coating, and methods for making and using the nanoparticle are provided. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, one or more of an associated targeting agent, fluorescent agent, or therapeutic agent. |
| 申请公布号 |
US2015320890(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514806162 |
申请日期 |
2015.07.22 |
| 申请人 |
University of Washington |
发明人 |
Zhang Miqin;Sun Conroy;Veiseh Omid;Bhattarai Narayan |
| 分类号 |
A61K49/18;A61K9/14;A61K49/00;A61K49/12;A61K49/08 |
主分类号 |
A61K49/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nanoparticle, comprising:
(a) a core having a surface and comprising a core material, wherein the core material is a magnetic material; and (b) a coating comprising a layer of a graft copolymer having a chitosan backbone and poly(ethylene oxide) oligomer side chains, the coating anchored to the surface of the core via amino and hydroxyl groups on the chitosan backbone. |
| 地址 |
Seattle WA US |
