Treatment determination and impact analysis

摘要

A method, software, database and system for determining an optimal treatment for an illness in an individual and for determining the impact (e.g., side effects and intended benefits) of the treatment in the individual are presented in which an attribute profile of the individual containing genetic and non-genetic attributes is compared against a database containing combinations genetic and non-genetic attributes that are statistically associated with successful treatment of the illness in other individuals.

主权项

1. A computer based method for determining a set of lifestyle modifications for an individual by identifying genetically referenced modifiable attributes associated with the individual, the method comprising:
a) receiving a query that is representative of a condition associated with a first individual; b) accessing an attribute profile associated with the first individual, the attribute profile comprising pangenetic and non-pangenetic attributes; c) accessing a database of attribute profiles of other individuals, the attribute profiles comprising pangenetic and non-pangenetic attributes; d) identifying, by analysis of a subset of attribute profiles of other individuals having the condition and the attribute profile associated with the first individual, a combination of at least two pangenetic attributes and at least one modifiable non-pangenetic attribute, wherein the combination is statistically associated with the condition and is also found in the attribute profile associated with the first individual, and wherein removal of the at least one modifiable non-pangenetic attribute from the combination results in a statistically significant altered probability of having the condition; and e) transmitting the at least one modifiable non-pangenetic attribute as a set of lifestyle modifications for the first individual, wherein the set of lifestyle modifications is ranked according to the greatest statistically significant altered probability of having the condition.