PHARMACEUTICAL COMPOSITIONS CONTAINING PIPERAZINE COMPOUNDS IN COMBINATION WITH A P450 INHIBITOR AND METHODS OF TERMINATING ACUTE EPISODES OF CARDIAC ARRHYTHMIA, RESTORING NORMAL SINUS RHYTHM, PREVENTING RECURRENCE OF CARDIAC ARRHYTHMIA AND MAINTAINING NORMAL SINUS RHYTHM IN MAMMALS THROUGH ADMINISTRATION OF SAID COMPOSITIONS

摘要

Disclosed embodiments are related to compositions of a piperazine compound and a P450 inhibitor, including compositions of a piperazine compound and one or more P450 inhibitors, and one or more diluents, disintegrants, binders and lubricants, and the processes for their preparation thereof.

主权项

1. A pharmaceutical composition comprising a piperazine compound of the formula: wherein each of R1, R2, and R3 is independently a hydrogen atom or a hydroxyl group, provided that not all of R1, R2 and R3 are the same, and further provided that R1 and R2 are not both a hydroxyl group and that R2 and R3 are not both a hydroxyl group, in combination with at least one P450 inhibitor, in an amount of from about 20-50% of the composition by weight; at least one P450 inhibitor from about 1-10% of the composition by weight, a diluent in an amount of from about 30-60% of the composition by weight; a binder in an amount of from about 15-25% of the composition by weight; a disintegrant in an amount of from about 1-5% of the composition by weight; a flowing agent from about 0.2-0.4% of the composition by weight; and a lubricant from about 0.2-0.4% of the composition by weight.