发明名称 |
Polymer backbone element tags |
摘要 |
Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats : bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood). |
申请公布号 |
EP2444804(B1) |
申请公布日期 |
2015.10.07 |
申请号 |
EP20110008035 |
申请日期 |
2007.05.28 |
申请人 |
FLUIDIGM CANADA INC. |
发明人 |
WINNIK, MITCHELL, A.;NITZ, MARK;BARANOV, VLADIMIR;LOU, XUDONG |
分类号 |
G01N33/53;C08F8/42;C08F220/36 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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