摘要 |
Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane. |
申请人 |
MERZ PHARMA GMBH & CO. KGAA |
发明人 |
HENRICH, MARKUS;NEGURA, SIMONA;TASI, GERGELY;KOCSN, PL;SBROGIO, FEDERICO;PYERIN, MICHAEL;KOLLER, HERBERT |