| 摘要 |
Disclosed is the use of viral oncolysates in the preparation of a complement-dependent, soluble antitumor factor having particular antitumor activity against ovarian carcinomas. The viral oncolysates employed in the preparation of the antitumor factor of the present invention is derived through the use of an influenza type. A strain PR8/34 virus, which is employed to modify the membranes of ovarian carcinoma cells in vitro without virally lysing these cells. The antitumor factor itself is prepared by administration of an effective amount of the viral oncolysate to an ovarian carcinoma patient bearing an ascites-producing ovarian carcinoma. Following treatment, the presence of the antitumor factor is elicited in the ascites of the individual. Ascites fluids bearing the antitumor factor are collected, and the antitumor factor is obtained therefrom. Also disclosed are particularly useful ovarian carcinoma cell lines for the preparation of oncolysates, the MDAH 2774 and the CaOV3 cell lines. |
