| 摘要 |
The present disclosure relates to the discovery that microRNAs of the invention, in particular miR-10a and miR-27a and functional variants thereof, inhibit cancer cell growth and enhance spontaneous, chemotherapy-induced, and growth factor deprivation-induced apoptosis in hematopoietic cancer cells, but not in normal hematopoietic progenitor/stem cells. Disclosed herein are methods, compositions and kits for the use of microRNAs of the invention, miR-10a and miR- 27a and functional variants thereof, in the treatment of cancer. |
