| 摘要 |
Process for making an amide of a carboxylic acid by reacting an amine of the formula (I) H-NR1R2, the integers being defined as being equal or different, R1 being selected from C1-C4-alkyl, R2 being selected from hydrogen and C1-C4-alkyl, R1 and R2 being combined in a way that amine according to formula (I) has a lower boiling point than water, with a carboxylic acid with at least 3 carbon atoms per molecule, said carboxylic acid optionally bearing at least one alcoholic hydroxyl group per molecule, selecting a molar ratio of amine according to formula (I) to carboxylic acid in the range of from 1.5 : 1 to 1 : 1, comprising the following measures: (a) reacting amine according to formula (I) with said carboxylic acid at temperature and pressure conditions at which water and amine according to formula (I) are gaseous, wherein the reaction (a) is performed in a single reactor, (b) distilling off the water formed, together with unreacted amine according to formula (I), (c) separating unreacted amine according to formula (I) from the water and (d) re-introducing said amine according to formula (I) into the reaction mixture in measure (a). |
