Enhancing a population of insulin releasing cells using GFR α-1 agonists

摘要

Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to activation of glial derived neurotrophic factor (GDNF) receptors or overexpression of the GFR-α1/c-Ret receptor complex in insulin secreting cells so as to promote cell survival and proliferation.

主权项

1. A method of enhancing a population of pancreatic islet cells for transplantation comprising culturing the population of pancreatic islet cells with an effective amount of a GDNF polypeptide having SEQ ID NO: 9 or variants with at least 80% sequence identity to SEQ ID NO: 9.