| 发明名称 | Compositions with polymerase activity | ||
| 摘要 | The invention provides novel compositions with polymerase activity and methods of using the compositions. | ||
| 申请公布号 | US9145550(B2) | 申请公布日期 | 2015.09.29 |
| 申请号 | US201313753207 | 申请日期 | 2013.01.29 |
| 申请人 | Bio-Rad Laboratories, Inc. | 发明人 | Vander Horn Peter B.;Wang Yan |
| 分类号 | C12N9/12 | 主分类号 | C12N9/12 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A polymerase that comprises a hybrid polymerase domain that has at least 94% identity to the amino acid sequence set forth in SEQ ID NO:12; or the polymerase region of SEQ ID NO:6, SEQ ID NO:8, or SEQ ID NO:10, wherein the hybrid polymerase domain has an increased ratio of polymerase activity to exonuclease activity relative to Pyrococcus sp. GD-B polymerase when joined to a sequence non-specific double-stranded nucleic acid binding domain. | ||
| 地址 | Hercules CA US | ||