Method for precipitating a solute from a solution

摘要

A solute is precipitated from a solution of a solute, a solvent, and a non-solvent by preparing the solution and introducing the solution into a precipitation chamber contain a supercritical fluid.

主权项

1. A method for producing particles of puerarin, the method comprising:
dissolving puerarin in an organic solvent to form a first solution, adding an organic non-solvent to the first solution, with agitation, to form a second solution, wherein
the second solution has a higher saturation ratio than the first solution,the organic non-solvent is miscible with the organic solvent, andthe puerarin is insoluble in the organic solvent, and spraying the second solution into a high pressure vessel containing a supercritical anti-solvent, under pressure, and contacting the second solution with the supercritical anti-solvent, thereby precipitating particles of puerarin having a mean particle size less than 2 μm and a narrower particle size distribution from the second solution.