发明名称 |
Compositions and methods for increasing vascularization |
摘要 |
Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject. |
申请公布号 |
US9138461(B2) |
申请公布日期 |
2015.09.22 |
申请号 |
US201213679529 |
申请日期 |
2012.11.16 |
申请人 |
Biogen MA Inc.;INSERM (Institut National de la Santé et de la Recherche Médicale) |
发明人 |
Rossomando Anthony;Silvestre Jean-Sebastien;Tamarat Radia |
分类号 |
A61K38/18;A61P9/10;A61P41/00;A61K45/06;C07K14/475 |
主分类号 |
A61K38/18 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A method of increasing vascularization in a tissue, the method comprising:
selecting a human exhibiting impaired or inadequate blood flow in a tissue; and administering to the human an amount of a polypeptide effective to increase vascularization in the tissue, wherein the polypeptide comprises an amino acid sequence that is at least 80% identical to amino acids 15-113 of SEQ ID NO:1, wherein the polypeptide, when dimerized, binds to a complex containing GFRalpha3 and RET, and wherein the human has received a transplanted organ and administration of the polypeptide increases vascularization in the transplanted organ. |
地址 |
Cambridge MA US |