作为选择性蛋白质激酶抑制剂之苯并咪唑衍生物;BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS

摘要

本发明系关于式I化合物或其医药上可接受之盐：;其中n、R1、R2、R3、R4、R5、A、Q及X系如说明书中所定义。;该等化合物选择性地调节、调控及/或抑制某些天然及/或突变蛋白质激酶介导之信号转导，该等激酶涉及各种人类及动物疾病，诸如细胞增殖、代谢、过敏及退化病症。更特别地，该等化合物系强效及选择性天然及/或突变c-kit抑制剂。;Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.