Histone demethylase inhibitors

摘要

The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

主权项

1. A compound having the structure of Formula (II): or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, or C6-C10aryl; R2 is C1-C5alkyl, C3-C8cycloalkyl, C6-C10aryl, C3-C8cycloalkyl(C1-C5alkylene), or C6-C10ar(C1-C5alkylene); R3 is hydrogen; R4 is —CO2H, —CO2R6, —C(O)N(H)CN, or —C(O)N(H)OH; each R5 is independently hydrogen, C1-C5alkyl, C3-C8cycloalkyl, C6-C10aryl, C3-C8cycloalkyl(C1-C5alkylene), or C6-C10ar(C1-C5alkylene); and R6 is C1-C5alkyl.