FORMULATION FOR THE TREATMENT OF PAIN

摘要

Formulations and methods are provided for the treatment of pain, and neuropathic pain in particular. The formulations are eutectic mixtures of a capsaicinoid and a local anesthetic agent and/or an anti-pruritic agent.

主权项

1. A substantially nonaqueous therapeutic formulation comprising a binary eutectic mixture of:
(a) a capsaicinoid having the structure of formula (I)wherein R1 is hydrogen, hydroxyl or methoxy, R2 is hydroxyl or C2-C6 alkoxycarbonyl, X is selected fromand R is selected from C5-C11 alkyl, C5-C11 alkenyl, C11-C23 cis-alkenyl, C11-C23 alkynyl, and C11-C23 alkadienyl, provided that the capsaicinoid is other than capsaicin; and
(b) a second active agent effective to decrease at least one side effect associated with capsaicin monotherapy, said second agent existing as a solid at 25° C.