发明名称 GENE SIGNATURES FOR CANCER PROGNOSIS
摘要 Biomarkers and methods using the biomarkers for classifying cancer in a patient (e.g., predicting the risk of cancer-specific death or cancer recurrence) are provided.
申请公布号 US2015247208(A1) 申请公布日期 2015.09.03
申请号 US201514713636 申请日期 2015.05.15
申请人 Myriad Genetics, Inc. 发明人 Stone Steven;Gutin Alexander;Wagner Susanne;Reid Julia
分类号 C12Q1/68 主分类号 C12Q1/68
代理机构 代理人
主权项 1. A method for determining a test patient's likelihood of cancer recurrence or cancer-specific death, comprising: (1) measuring, in a sample obtained from said test patient, the expression levels of a panel of genes comprising at least 3 test genes selected from Panel F; (2) providing a test expression score by (a) weighting the determined expression of each gene in said panel of genes with a predefined coefficient (which may be 0), and (b) combining the weighted expression of each gene in said panel of genes to provide said test expression score, wherein said test genes are weighted to contribute at least 25% to said test expression score; and (3) diagnosing said test patient as having either (a) an increased likelihood of cancer recurrence or cancer-specific death based at least in part on said test expression score exceeding a first reference expression score or (b) no increased likelihood of cancer recurrence or cancer-specific death based at least in part on said test expression score not exceeding a second reference expression score.
地址 Salt Lake City UT US