发明名称 |
ANTIGEN-BINDING MOLECULE FOR PROMOTING LOSS OF ANTIGENS |
摘要 |
The present inventors created antigen-binding molecules containing an antigen-binding domain and an Fc³-receptor-binding domain, wherein the molecules have human-FcRn-binding activity in an acidic pH range condition, the antigen-binding domain changes the antigen-binding activity of the antigen-binding molecules depending on the ion-concentration condition, and the Fc³ receptor-binding domain has higher binding activity to the Fc³ receptor in a neutral pH range condition than an Fc region of a native human IgG in which the sugar chain bound at position 297 (EU numbering) is a fucose-containing sugar chain. |
申请公布号 |
EP2762166(A4) |
申请公布日期 |
2015.08.26 |
申请号 |
EP20120835590 |
申请日期 |
2012.09.28 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;MAEDA, ATSUHIKO;HARAYA, KENTA;IWAYANAGI, YUKI;TACHIBANA, TATSUHIKO |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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