Anti-glycation agent comprising a <i>Garcinia kola </i>extract or fraction

摘要

An anti-glycation agent includes a Garcinia kola extract or fraction. The compositions including the extract or the fraction are used to inhibit the glycation of proteins, in particular the glycation of skin proteins involved in cutaneous aging. A method for determining the activity of compounds for inhibiting the glycation of cutaneous proteins, in particular for inhibiting the glycation of collagen is also described.

主权项

1. A cosmetic treatment method for inhibiting glycation of proteins, comprising applying to the skin of a subject a cosmetic composition to inhibit glycation of proteins, wherein said cosmetic composition comprises:
an anti-glycation agent including a Garcinia kola extract, said Garcinia kola extract comprising a total biflavonoid concentration of more than 5% biflavonoids expressed in GB2 equivalents, assayed by HPLC-UV at 290 nm, wherein at least one of said biflavonoids is selected from the group consisting of GB1, GB1a, GB2 and kolaflavanone, and wherein said Garcinia kola extract is 0.1 to 2% by weight of said cosmetic composition; and at least one compound selected from the group consisting of consistency factors, emollients, emulsifiers, surfactants, thickeners, moistening agents, gelling agents, fragrances, preservatives, dyes and pH adjusters.