发明名称 |
Compounds and compositions as hedgehog pathway modulators |
摘要 |
<p>The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.</p> |
申请公布号 |
EP2363393(B1) |
申请公布日期 |
2015.08.12 |
申请号 |
EP20110165059 |
申请日期 |
2007.05.04 |
申请人 |
NOVARTIS AG |
发明人 |
GAO, WENQI;JIANG, JIQING;WAN, YONGQIN;CHENG, DAI;HAN, DONG;WU, XU;PAN, SHIFENG |
分类号 |
C07D213/75;A61K31/4433;A61P35/00;C07C233/65;C07C233/75;C07D239/49;C07D295/135;C07D295/26;C07D401/04;C07D401/12;C07D401/14;C07D405/12;C07D409/12;C07D413/04 |
主分类号 |
C07D213/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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