SOGA polynucleotides and polypeptides and uses thereof

摘要

The present invention relates to the identification of polynucleotides and polypeptides involved in insulin and adiponectin signaling and regulation of glucose production. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of glucose production and the monitoring and treatment of metabolic disorders such as diabetes.

主权项

1. An antibody or antibody fragment that specifically binds to a polypeptide encoded by a polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising a nucleotide sequence at least 95% identical to a nucleotide sequence selected from the group consisting of SEQ ID NOS:1 and 3 and encoding a functional Suppressor of Glucose by Autophagy (SOGA) polypeptide; (b) a polynucleotide encoding a functional SOGA polypeptide comprising an amino acid sequence at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NOS:2 and 4; (c) a polynucleotide of (a) or (b) encoding a C-terminal functional fragment of a SOGA polypeptide of about 80 kDa; and (d) a polynucleotide of (a) or (b) encoding a C-terminal functional fragment of a SOGA polypeptide of about 25 kDa.