发明名称 METHODS AND DEVICES FOR ANALYZING SPECIES TO DETERMINE DISEASES
摘要 The present invention, in some embodiments thereof, generally relates to methods and devices for determining the health status of a subject, e.g., whether the subject has a disease or other condition. In some embodiments, a plurality or mixture of species may be differentially solubilized in a single two-phase aqueous system, or other multi-phase aqueous system. The nature or degree of the solubilization of the species may be used to determine the health status of a subject. For example, some embodiments are directed to devices and methods for determining a disease or other condition as a function of the changes to the structure of two or more species. The species may be selected based on their differential solubility behavior in a two-phase or other multi-phase aqueous system. Preferential enrichment of the species concentrations in one of the phases, and/or the ratios of species in the phases may be determined, and in some cases compared to their respective values for healthy and/or diseased subjects to determine the health status of the subject.
申请公布号 US2015219655(A1) 申请公布日期 2015.08.06
申请号 US201314420166 申请日期 2013.08.08
申请人 Analiza, Inc. 发明人 Chait Arnon;Zaslavsky Boris Y.
分类号 G01N33/574;G06F19/00 主分类号 G01N33/574
代理机构 代理人
主权项 1. A method for diagnosing a cancer, the method comprising: partitioning a biological fluid from a subject in an aqueous two-phase partitioning system; assaying aqueous phases of said two phase partitioning system for a plurality of species, using at least one assay specific for said each species; calculating a partition coefficient K for each species, wherein K is a ratio of amount of dissolved species in each aqueous phase of said two phase partitioning system; and determining presence or risk level of said cancer in said subject by comparing the calculated partition coefficients with reference values.
地址 Bay Village OH US