Autologous Cell-Based Therapy for Treating Obesity

摘要

Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ASCs) to a site in the body of a subject. These ASCs may then be isolated and induced to differentiate into autologous brown adipose cells. Alternatively, the drug delivery device may also include differentiation factors that induce differentiation of the recruited ASCs into brown adipose cells in vivo. The brown adipose cells produced by these methods may be used therapeutically to treat conditions, such as obesity and diabetes.

主权项

1. A drug delivery system for recruiting adipose stem cells (ASCs) to a site in the body of a subject, wherein the system comprises a plurality of particles, fibers, or films comprising one or more soluble ASC recruitment factors releasably incorporated therein, wherein the one or more ASC recruitment factors are released from the drug delivery system when implanted in a subject in an effective amount to recruit ASCs.