发明名称 |
PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA |
摘要 |
The present invention provides a use of lithium amide in liquid ammonia as a base to produce an enolate from at least one ester starting material in a crossed Claisen condensation reaction, wherein at least one ester starting material is a β-hydroxy ester. Also provided is a method of producing lithium amide in situ for use in a crossed Claisen condensation reaction, wherein lithium is added to liquid ammonia, followed by an electron transfer agent, as well as a method of carrying out a crossed Claisen condensation reaction using an ester starting material and a β-hydroxy ester, using lithium amide in liquid ammonia produced in situ. |
申请公布号 |
US2015197476(A1) |
申请公布日期 |
2015.07.16 |
申请号 |
US201314415523 |
申请日期 |
2013.07.18 |
申请人 |
Bakhu Pharma Limited |
发明人 |
Leece Colin;Proctor Lee David |
分类号 |
C07C67/343;C01B21/092 |
主分类号 |
C07C67/343 |
代理机构 |
|
代理人 |
|
主权项 |
1. A use of lithium amide in liquid ammonia as a base to produce an enolate from at least one ester starting material in a crossed Claisen condensation reaction, wherein at least one ester starting material is a β-hydroxy ester. |
地址 |
Wirral GB |