| 发明名称 | Products comprising inactivated yeasts or moulds and active VHH-type antibodies | ||
| 摘要 | The use of VHHs in the preparation of products to provide stability of antibody specificity under destabilizing conditions whereby normally lower eukaryotes or traditional antibodies are killed or inactivated. | ||
| 申请公布号 | US9080157(B2) | 申请公布日期 | 2015.07.14 |
| 申请号 | US201213462262 | 申请日期 | 2012.05.02 |
| 申请人 | BAC IP B.V. | 发明人 | Convents Daniel;Frenken Leo G.;Harmsen Michael M.;van der Linden Richard H.;Verrips Cornelis T. |
| 分类号 | A61K49/16;A61K39/40;C12Q1/68;C12P21/08;C12P19/34;C12N1/16;A23L1/305;A61K8/64;A61Q5/02;A61Q15/00;A61Q19/00;A61Q19/10;C07K1/14;C11D17/00;C12N1/14;C07K16/00;C07K16/12 | 主分类号 | A61K49/16 |
| 代理机构 | MH2 Technology Law Group, LLP | 代理人 | MH2 Technology Law Group, LLP |
| 主权项 | 1. A method of preparing a product, the method comprising: (i) identifying a VHH antibody that retains: (a) at least 70% of its original antigen binding activity following incubation at 80° C. for two hours, and(b) functional activity following exposure to the gastrointestinal tract of an animal; and (ii) incorporating into the products the VHH antibody identified in step (i). | ||
| 地址 | Naarden NL | ||