RED-SHIFTED OPSIN MOLECULES AND USES THEREOF

摘要

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion pumps (LAIPs).

主权项

1. A vertebrate cell comprising a light-activated ion pump polypeptide that when expressed in a mammalian excitable cell and contacted with a red light silences the excitable cell, wherein the polypeptide sequence of the light-activated ion pump comprises an amino acid sequence set forth herein as SEQ ID NO:2, with one, two, or more amino acid sequence modifications, and wherein the polypeptide has at least 70% amino acid identity to the sequence set forth as SEQ ID NO:2.